Epilepsy and Thyroid Hormones
نویسندگان
چکیده
منابع مشابه
Thyroid hormones: Possible roles in epilepsy pathology
Thyroid hormones (THs) L-thyroxine and L-triiodothyronine, primarily known as metabolism regulators, are tyrosine-derived hormones produced by the thyroid gland. They play an essential role in normal central nervous system development and physiological function. By binding to nuclear receptors and modulating gene expression, THs influence neuronal migration, differentiation, myelination, synapt...
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Hormones are crucial systemic players and act at different sites of the entire body including the brain. The brain is not only the target of hormone action, but also serves as the “conductor” of the “neuro-endocrine symphony”. Changes in neuronal activity, such as seizures in epileptic patients, may affect hormonal regulation and secretion. In turn, hormones modify susceptibility to develop sei...
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An extensive review article on thyroid hormone published nearly 40 years ago (Barker, 1951) might have led one to suppose that little could be added to the subject of thyroid hormones and thermogenesis. However, a large number of new ideas have since emerged with respect to the mechanisms of action of thyroid hormones, although there is still considerable uncertainty as to how they function at ...
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Thyroid hormones are the master regulator of body metabolism and growth. They act at molecular level to manipulate genes and cellular functions to balance the basic metabolic rate. They bind to superfamily of nuclear receptors that recognize discrete sequences of DNA and act as transcription factors (Renkawitz et al., 1996). At the cellular level, thyroid hormones act directly on the mitochondr...
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C O N T E N T S ABBREVIATIONS I. Tin,on3 HORMONE MECHANISMS A. Calorigenic and anabolic effects B. Thyroid hormone entry into cells II. LIPID METAeOLISM A. Cell lipid composition B. Fatty acid synthesis 1. Protein phosphorylation-dephosphorylation 2. Gene expression C. NADPH generation and oxidation 1. Cytoplasm: NADP+--*NADPH 2. Mitochondria: NADP + + NADH,NADPH + NAD + 3. Microsomes: NADPH-*N...
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ژورنال
عنوان ژورنال: Journal of the Turkish Epilepsi Society
سال: 2018
ISSN: 1300-7157
DOI: 10.14744/epilepsi.2018.78942